Regulation of Gene Expression by Action
Potentials
Eshete, F., and R.D. Fields (2001) Spike frequency decoding by autonomous activation of CaMKII in DGR neurons. J. Neuroscience 21: 6694-6705 PDF
Itoh, K., M. Ozaki, B. Stevens, and R.D. Fields (1997) Activity-dependent regulation of N-cadherin in DRG neurons: Differential regulation of N-cadherin, NCAM, and L1 by distinct patterns of action potentials. J. Neurobiology 33: 735-748. PDF
Itoh, K., B. Stevens, M. Schachner and R.D. Fields (1995) Regulation of the neural cell adhesion molecule L1 by specific patterns of neural impulses. Science 270: 1369-1372.
Klein, J.P., E.A. Tendi, Dib-Hajj, S.D., R.D. Fields, and S.G. Waxman (2003) Patterned electrical activity modulates sodium channel expression in sensory neurons. J. Neuroscience Research 74: 192-198. PDF
Stevens, B., S. Tanner, and R.D. Fields (1998) Control of myelination by specific patterns of neural impulses. J. Neuroscience 15: 9303-9311.
Intracellular Signaling From Action Potentials
Buonanno, A, and R.D. Fields (1999) Patterned electrical activity and gene regulation in neural development. Current Opinion Neurobiology 9:110-120. PDF
Cohen, J.E. and R.D. Fields (2006) CaMKII activation by extracellular Ca2+ depletion in dorsal root ganglion neurons. Cell Calcium 39(5): 445-54 PDF
Fields, R.D., F. Eshete, B. Stevens, K. Itoh (1997) Action potential-dependent regulation of gene expression: Temporal specificity in Ca++, CREB, and MAP kinase signaling. J. Neuroscience 17: 7252-7266. PDF
Neuron-Glia Communication
Fields, R.D. and B. Stevens (2000) ATP in signaling between neurons and glia. Trends in Neuroscience 23:625-633. PDF
Jia, M., Li, M. -X., Fields, R.D., and Nelson, P.G. (2007) Extracellular ATP in activity-dependent remodeling of the neuromuscular junction. J. Neurobiology (in press). PDF
Lee, P.R., Cohen, J.E., Fields, R.D. (2006) Immune system evasion by peripheral nerve sheath tumor. Neurosci Lett 397(1-2):126-9. PDF
Lee, P.R., J.E. Cohen, E.A. Tendi, G.H. DeVries, K.G. Becker and R.D. Fields (2005) Transcriptional profiling of an MPNST-derived cell line and normal human Schwann cells. Neuron Glia Biology 1: 135-147. PDF
Stevens, B., Ishibashi, T., Chen, J.-F., and R.D. Fields (2004) Adenosine: an activity-dependent axonal signal regulating MAP kinase and proliferation in developing Schwann cells. Neuron Glia Biology 1: 23-34. PDF
Stevens, B. and R.D. Fields (2000) Action potentials regulate Schwann cell proliferation and development. Science 287: 2267-2271.
Synaptic Plasticity
Dudek, M.S. and R.D. Fields (2002) Somatic action potentials are sufficient for late-phase LTP-related cell signaling. Proc. Natl. Acad. Sci. USA 99: 3962-3967. PDF
Dudek, M.S. and R.D. Fields (2001) Mitogen-activated protein kinase/extracellular signal-regulated kinase activation in somatodendritic compartments: Roles of action potentials, frequency and mode of calcium entry. J. Neuroscience 21, RC122:1-5. PDF
Fields, R.D. and K. Itoh (1996) Neural cell adhesion molecules in activity-dependent development and synaptic plasticity. Trends Neurosciences 19:473-480.
Fields, R.D., Lee, P.R., and Cohen J.E. (2005) Gene Expression in the Conversion of Early-Phase to Late-Phase Long-Term Potentiation. Annals of the New York Acad. Sci. 1048: 259-271.
Functional Effects of Impulse Activity on Nervous System Development
Stevens, B. and R.D. Fields (2000) Action potentials regulate Schwann cell proliferation and development. Science 287: 2267-2271.
Stevens, B., S. Tanner, and R.D. Fields (1998) Control of myelination by specific patterns of neural impulses. J. Neuroscience 15: 9303-9311. PDF
Itoh, K., B. Stevens, M. Schachner and R.D. Fields (1995) Regulation of the neural cell adhesion molecule L1 by specific patterns of neural impulses. Science 270: 1369-1372.
Review Articles
Fields, R.D. (2007) Electroreception in Sharks. Scientific American (IN PRESS)
Fields, R.D. (2007) New Brain Cells Go to Work. Scientific American Mind 18:31-35.
Fields, R.D. (2007) Sex and the Secret Nerve. Scientific American Mind 18:20-27.
Fields, R.D. (2006) Beyond the Neuron Doctrine. Scientific American Mind 17:20-27.
Fields, R.D. (2006) Erasing Memories. Scientific American Mind 16:28-37.
Fields, R.D. and Burnstock, G. (2006) ;Purinergic signaling in neuron-glia interactions. Nature Reviews Neuroscience June;7(6):423-36. PDF
Bullock, T.H., Bennett, M.V. L., Johnston, D., Josephson, R., Marder, E., Fields, R.D. (2005) The Neuron Doctrine, Redux. Science 310: 791-793. PDF
Fields, R.D. (2005) Myelination: an overlooked mechanism of synaptic plasticity? Neuroscientist 11(6):528-31. PDF
Fields, R.D. (2005) Making Memories Stick. Scientific American 292(February), 74-81.
Fields, R.D. (2004) The other half of the brain. Scientific American 290(4)(April)54-61.
Fields, R.D. and B. Stevens-Graham (2002) New insights into neuron-glia communication. Science 298: 556-562. PDF
Fields, R.D. and B. Stevens (2000) ATP in signaling between neurons and glia. Trends in Neuroscience 23:625-633.
Buonanno, A, and R.D. Fields (1999) Patterned electrical activity and gene regulation in neural development. Current Opinion Neurobiology 9:110-120. PDF
Fields, R.D. (1998) Effects of ion channel activity on development of DRG neurons. J. Neurobiology 37:158-170. PDF
Fields, R.D. and K. Itoh (1996) Neural cell adhesion molecules in activity-dependent development and synaptic plasticity. Trends Neurosciences 19:473-480.
Activity Dependant Myelination
Ishibashi, T. Dakin, K.A., Stevens, B., Lee, P.R., Kozlov, S.V., Stewart, C.L., Fields, R.D. (2006) Astrocytes promote myelination in response to electrical impulses. Neuron. 49(6):823-32. PDF
Fields, R.D. (2004) Volume transmission in activity-dependent regulation of myelinating glia. Neurochemistry International 45:503-509. PDF
Stevens, B., S. Porta, L.L. Haak, V. Gallo, and R.D. Fields (2002) Adenosine: A neuron-glial transmitter promoting myelination in the CNS in response to action potentials. Neuron 36:855-868. PDF
Stevens, B., S. Tanner, and R.D. Fields (1998) Control of myelination by specific patterns of neural impulses. J. Neuroscience 15: 9303-9311.